To screen and evaluate the efficacy of antiviral drugs in duck animal model
- VernacularTitle:鸭乙型肝炎动物模型考核抗病毒药物的疗效观察
- Author:
Yi TAN
;
Shimin GU
;
Longting FU
;
Rende SONG
;
Haitao TONG
;
Weimin XU
;
Shanming WU
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus,duck;
DNA,viral;
Adefovir;
Entecavir;
Entecavir Maleate;
Disease models,animal
- From:
Chinese Journal of Infectious Diseases
2008;26(6):329-335
- CountryChina
- Language:Chinese
-
Abstract:
0bjective To study the potency of Entecavir Maleate(ETVM),Entecavir(ETV) and Adefovir(ADV) on suppressing duck hepatitis B virus (DHBV) replication.Methods DHBV DNA positive ducks were used as experimental animal model.Ail these ducks were randomized to different arms and respectively given high,medium and low dosage of ETVM,ETV and ADV.ETVM and ETV were given orally daily respectively for six weeks and ADV orally 3 times every week for six weeks.The serum DHBV DNA levels were tested every 2 weeks at day 0 and,after that,at week 2,4.6 and 8 respectively by real-time fluorescent quantitative polymerase chain reaction(PCR).The results were analyzed by paired-samples t test.Results The treatment resulted in the reduction of viral load among all ETVM.ETV or ADV treated groups.The viral load of DHBV DNA at pretreatment and week 6 in the ETVM high dosage group were(7.34±1.33)and(2.12±2.50)lg copy/mL,respectively(P
