Influencing factor of mechanical ventilation time in patients with chronic obstructive pulmonary disease
- VernacularTitle:慢性阻塞性肺疾病患者机械通气时间的影响因素
- Author:
Hui LIU
;
Tiantuo ZHANG
;
Jing HUANG
;
Benquan WU
;
Yuqi ZHOU
;
Jiaxin ZHU
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Mechanical ventilation;
Respiratory failure;
Risk factor;
Ventilator-associated pneumonia
- From:
Chinese Journal of Emergency Medicine
2008;17(7):730-734
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study influencing factor of mechanical ventilation (MV) time in patients withchronic obstructive pulmonary disease (COPD). Method Totally 128 patients with COPD and respiratory failurerequiting ventilation support were retrespectively investigated. The clinical characteristics of patients before and af-ter intuhation during the respiratory intensive care unit (RICU) stay were recorded and analyzed, t- test, X2 testand stepwise logistic regression analysis were used for statistical analysis. Results In the 128 patients, 61%,20%, and 9% of the patients required MV longer than 7, 14 and 21 days, respectively. There were no significantdifferences in the history of COPD, smoking, lung function, and complications between patients with MV>7 d, 14d, 21 d and patients with MV<7 d, 14 d, 21 d. Multiple regression analysis showed APACHE Ⅱ score (OR:2.3; 95% Ca: 1.2-5.7, P = 0.02) was an independent factor for MV > 7 days, while shock (OR: 0.7;95% CI: 1.0-1.9, P = 0.04) and decreased serum albumin (OR: 0.4, 95% CI: 0.2-0.8, P = 0.003)were an independent factors for MV > 21 days. The ventilator-associated pneumonia (VAP) was the most impor-rant risk factor for the time of MV. Conclusions APACHE Ⅱ score, serum albumin levels, hock and VAP arethe main factors affecting MV time in patients with COPD.
