Effect of spironolactone on the left ventricular remodeling in patients with acute myocardial infarction
- VernacularTitle:螺内酯对急性心肌梗死患者左心室重构的影响
- Author:
Mingjun YANG
- Publication Type:Journal Article
- Keywords:
Spironolactone;
Myocardial infarction;
Ventricular remodeling
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(6):891-892
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of apironolactone on the left ventricular remodeling(LVRM) in patients with acute myocardial infarction (AMI). Methods 90 patients with AMI were randomly divided into spironolactone group( n = 45 ) and control group( n = 45 ). Spironolactone 40mg/d was administered in addition to the routine treatment for spironolactone group; the control group was received the routine treatment. All patients with AMI were examined left ventficular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD) and LVEF on 7 days and 90 days by ultrasonic cardiogram(UCG). Results Two groups patients with AMI in each UCG parameter had no significant difference on 7 days(P > 0.05); LVEDD, LVESD of spironolactone group on 90 days were significantly lower than that in control group(P < 0.05) and LVEF of spironolaetone groupwas significantly higher than that in control group(P < 0.05). Conclusion Those findings indicate that in patients with AMI, spironolactone may prevent LVRM.
