Effect of pravastatin on levels of TNF-α and interleukin-6 in patients with acute coronary syndrome
- VernacularTitle:普伐他汀对急性冠状动脉综合征患者血清TNF-α和IL-6水平的影响
- Author:
Mei YANG
;
Dongliang YIN
;
Lin XING
- Publication Type:Journal Article
- Keywords:
Pravastatin;
Interleukin-6;
Tumor necrosis factor;
Coronary disease
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(6):942-944
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of pravastatin on serum levels of interleukin-6(IL-6) and tu- mor necrosis faetor-α(TNF-α) in patients with acute coronary syndromes(ACS). Methods50 patients with ACSwere randomly divided into pravastatin group( n = 25) and routine therapy group( n = 25). Serum TNF-α and IL-6levels were measured before and four weeks after the two treatment options respectively. ResultsThe level of TNF- α and IL-6 were higher than routine therapy group before therapy(P < 0.01 ). The level of TNF-α and IL-6 weredecreased significantly after pravastatin therapy,and higher thancontrols(P < 0.05). The levels of TNF-α and IL-6changed only slightly after the routine therapy(P > 0.05). ConclusionThe level of TNF-α and IL-6 becominghigher in ACS patients may be related to the pathogenesis of ACS. Pravastatin can reduce serum level of TNF-α and IL-6 contributing to treatment of ACS.
