Clinical evaluation of intermittent low-dosage cyclophosphamide in the treatment of 12 eases with lu-pus nephritis related chronic renal insufficiency
- VernacularTitle:间歇小剂量环磷酰胺治疗12例狼疮肾炎慢性肾功能不全的临床分析
- Author:
Guohua ZHANG
;
Xiaofeng LI
;
Caihong WANG
- Publication Type:Journal Article
- Keywords:
Cyclophosphamide;
Lupus nephritis;
Kidney failure,chronic;
Therapies,investiga-tional
- From:
Chinese Journal of Rheumatology
2008;12(7):484-486
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of intermittent low-dosage intravenous (Ⅳ) cyelophosphamide (CTX) in treating lupus nephritis (LN) related chronic renal insufficiency. Methods Twelve patients with chronic renal insufficiency with azotemia caused by lupus nephritis received intermittent low-dosage eyclophosphamide therapy (200-400 mg/2～4 weeks) for 2 month to 5 years. We monitored their clinical outcomes and laboratory parameters changes. Results SLEDAI significantly decreased in all cases. Renal function was improved in varying grees. Nine cases had their renal function tests returned to normal range and another 3 cases were still in azotemia. No severe adverse effects occurred. Conclusion The treatment is effective and safe. But it is necessary to carry out large samples and long-term follow-up clinical studies to evaluate its effects on renal function changes.
