Influence of aging on motor function and striatum dopamine transporter of rats
- VernacularTitle:增龄对大鼠运动功能和纹状体多巴胺转运体的影响
- Author:
Yanbo CHENG
;
Weidong HU
;
Jinjun QIAN
;
Kangyong LIU
;
Chunfeng LIU
- Publication Type:Journal Article
- Keywords:
Aging;
Parkinson disease;
Movement disorders;
Dopamine plasma membrane transport proteins
- From:
Chinese Journal of Geriatrics
2008;27(7):541-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of aging on motor function,binding activity and protein expression level of striatum dopamine transporter(DAT)of rats. Methods Rolling-bar test was performed to assess motor function.Western blot and 131I-FP-β-CIT up-take ratio were used to evaluate DAT protein 1evel and striatum DAT binding activity respectively. Results There were an age-related decline of rolling-bar latency and striatum 131I-FP-β-CIT up-take ratio in rats older than6 months.There was a significant difference between 6-month-old rats and older rats(12-month-old rats,16-month-old rats,20-month-old rats),and rolling-bar latency was correlated with striatum 131I-FP-β-CIT up-take ratio(r=0.656,P＜0.01).There was no change in DAT protein 1evel during aging process. Conclusions The age-related decline of motor function of rats was correlated with the decreasing of striatum DAT binding activity.The synaptic membrane expression of striatum DAT may decrease in aged rats.
