EGFR-targeted treatment in non-small-cell lung cancer
- VernacularTitle:非小细胞肺癌表皮生长因子受体靶向治疗
- Author:
Jiying WANG
;
Yong CAI
- Publication Type:Journal Article
- Keywords:
Receptor,epidermal growth factor;
Carcinoma,non-small-cell lung
- From:
Journal of International Oncology
2008;35(6):438-440
- CountryChina
- Language:Chinese
-
Abstract:
Epidermal growth factor receptor (EGFR) is necessary in normal epithelial cell growth. Ab-errant EGFR expression is linked with increased cell proliferation and decreased apoptosis. Mutations and over-expression of EGFR are common features of many cancers. Therefore, Therapeutic agents that target the EGFR signal pathway, such as small-molecule tyrosine kinase inhibiiors and monoclonal antibodies are now advanced in clinical development. EGFR-targeted therapies of non-small-cell lung cancer (NSCLC) have been studied as a new way.
