The Roles of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Its Receptors in Central Nervous System Diseases
- VernacularTitle:肿瘤坏死因子相关性凋亡诱导配体及其受体在中枢神经系统疾病中的作用
- Author:
Hongguang FAN
;
Ying LIN
;
Chenhui YANG
;
Xiangjian ZHANG
- Publication Type:Journal Article
- Keywords:
tumor necrosis factor-related apoptosis-inducing ligand;
central nervous system disease;
apoptosis;
primary brain tumor;
multiple sclerosis;
ischemic stroke
- From:
International Journal of Cerebrovascular Diseases
2008;16(6):473-476
- CountryChina
- Language:Chinese
-
Abstract:
Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)is the third member of the tumor necrosis factor(TNF)superfamily.It has received much concern because of its selective killing effect on tumor cells and virus infected cells.However,the subsequent studies have suggested that TRAIL also induces normal cells,such as the death of neurons and oligodendrocytes.TRAIL is associated with a variety of central nervous system diseases including primary brain tumor,multipie sclerosis and ischemic stroke.
