The curative effect study of edaravone on patients with acute lagre areacerebellar infarction
- VernacularTitle:依达拉奉治疗急性大面积脑梗死的疗效观察
- Author:
Yulan LIU
- Publication Type:Journal Article
- Keywords:
Edaravone;
Cerebellar infarction;
Reactive nitrogen species
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(6):957-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical curative effect of edaravone on treatment of acute lagre area cerebellar irdarction(ALACI). Methods 31 ALACI patients attacked within 72h were randomly assigned to therapygroup( n = 16) and control group( n = 15). Therapy group took the basic treatment as well as edaravone infused at a dose of 30mg,twice a day for 14 days. Control group took similar treatment to therapy group expect for edaravone.At 0th ,7th, 14th ,21th day after treatment, the C.SS and ability of daily living(ADL) were used to evaluate the recovery of neurological functions. Results Significant difference of CSS and ADL grading were detected between therapygoup and control group at 7th, 14th day( P < 0.05 ), with lower grading in therapy group ; there were significant differ-ence of CSS and ADL grading between therapy goup and control group at 21th day( P < 0.01 ), with lower grading in therapy group. No evident side effect was detected in edaravone therapy group. Conclusion Edaravone is a safe a-gent. It can effectively improve the neurological deficits and daily living ability of ALACI patients.
