Relationship between expression of MMP-9, p53 and the clinicpathological in primary hepatocarcinoma
- VernacularTitle:原发性肝癌组织中MMP-9、p53的表达与临床病理之间的关系
- Author:
Wenli ZHAO
- Publication Type:Journal Article
- Keywords:
Liver neoplasrns;
Gelatinase B;
Genes,p53;
Immunohistochemistry;
Pathology,clinical
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(6):959-961
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of MMP-9, p53 protein in primary hepatocarcinoma (PHC) and the relationship between the clinicpathological in PHC. Methods The expression of MMP-9 and p53 in 74 eases with PHC and microvessel density(MVD) were detected by immunohistochemistry,the clinical pathological parameters were also analyzed. Results In hepato-cellular carcinoma, the expression of MMP-9 and p53 were closely related to MVD, tumor size, aggressive behavior(vascular metastasis and tumor envelope) ( P < 0.05 ). The positive correlation was found between the expression of two factors in PHC. Conclusion MMP-9 and p53 might be impor-tant markers in the carcinogenesis,progression and prognosis of PHC.
