Development of Thyroid-Associated Ophthalmopathy in Patients Who Underwent Total Thyroidectomy.
10.3349/ymj.2015.56.5.1389
- Author:
Sun Young JANG
1
;
Ka Hyun LEE
;
Jong Rok OH
;
Bo Yeon KIM
;
Jin Sook YOON
Author Information
1. Department of Ophthalmology, Soonchunhyang Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Total thyroidectomy;
thyroid-associated orbitopathy;
TSH receptor autoantibody;
thyroid cancer;
thyroid benign mass
- MeSH:
Adult;
Aged;
Autoantibodies/blood;
Carcinoma;
Carcinoma, Papillary/immunology/surgery;
Female;
Graves Ophthalmopathy/*diagnosis/immunology;
Humans;
Male;
Middle Aged;
Postoperative Complications/etiology/immunology/pathology;
Receptors, Thyrotropin;
Retrospective Studies;
Thyroid Neoplasms/complications/*surgery;
Thyroidectomy/adverse effects/*methods;
Thyrotropin/blood;
Treatment Outcome
- From:Yonsei Medical Journal
2015;56(5):1389-1394
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To report clinical characteristics of thyroid-associated ophthalmopathy (TAO) in patients who previously underwent total thyroidectomy for thyroid cancer or a benign mass of the thyroid. MATERIALS AND METHODS: Of the patients who were diagnosed with TAO from March 2008 to March 2012, we performed a retrospective chart review on those who had undergone total thyroidectomy for thyroid cancer or a benign mass of the thyroid before the occurrence of ophthalmopathy. RESULTS: Of the 206 patients diagnosed with TAO, seven (3.4%) met the inclusion criteria. The mean age of the subjects was 47.4 years, and all were female. Six patients were diagnosed with papillary thyroid cancer, and one was diagnosed with a benign mass. The duration between total thyroidectomy and onset of TAO ranged from 3-120 months (median 48 months). Ophthalmic manifestations varied among cases. Except for the patient who was diagnosed with a benign mass, all patients showed hyperthyroid status and were under Synthroid hormone treatment at the time of TAO development. Five of these six patients had positive levels of thyroid-stimulating hormone (TSH) receptor autoantibodies. CONCLUSION: TAO rarely develops after total thyroidectomy, and the mechanism of TAO occurrence is unclear. However, most patients showed abnormalities in thyroid function and TSH receptor autoantibodies.
