Malondialdehyde and inflammatory factors testing for patients with autoimmune thyroid diseases
- VernacularTitle:自身免疫性甲状腺疾病患者血浆丙二醛与炎症因子的检测及临床意义
- Author:
Peiyi DU
;
Beichun HUANG
;
Song DU
;
Xiuqin ZHAO
;
Jing PEN
;
Sanji LI
- Publication Type:Journal Article
- Keywords:
Thyroid diseases;
Malondialdehyde
- From:
Chinese Journal of General Practitioners
2008;7(7):483-485
- CountryChina
- Language:Chinese
-
Abstract:
One hundred and seventeen patients with newly diagnosed autoimmune thyroid diseases(AITDs)and 30 normal controls(NCs)were selected.All the patients were divided into 5 groups:hyperthyroidism group(n=33),subclinical hyperthyroidism group(n=21),hypothyroidism group(n=25),subclinical hypothyroidism group(n=23)and euthyroidism group(n=15).Plasma malondialdehyde(MDA),superoxide(SOD)and inflammatory factors levels were measured.Our results showed that plasma MDA level in dysthyroidism groups was significantly higher than that in NCs group(P＜0.05 or P＜0.01).SOD/MDA ratio in AITD groups Was significantly lower than that in NCs group(P＜0.05 or P＜0.01).In a multiple step-wise regression analysis,serum hishly sensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)were independent factors of MDA.This study might suggest that plasma MDA level in AITD patients receiving no treatment may increase.MDA may be correlated with hs-CRP or TNF-α levels.
