Relationship between plasminogen activator inhibitor 1 gene polymorphism and the level of endothelium-de- pendent vasodilatation in patients with type 2 diabetes
- VernacularTitle:人类纤溶酶原激活物抑制物-1基因多态性与2型糖尿病血管内皮功能的关系
- Author:
Xiaofang YAN
;
Shizhong PAN
;
Sunjie YAN
;
Songqing ZHANG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Plasminogen activator inhibitor;
Gene;
Polymorphism
- From:
Clinical Medicine of China
2008;24(7):708-710
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the polymorphisms of plasminogen activator inhibitor-1(PAI-1)gene and the level of endothelium-dependent vasodilatation (EDF) in patients with type 2 diabe- tes(T2DM).Methods The polymorphisms of PAI-1(4G/5G)gene were determined by polymerase chain reaction (PCR)and the EDF was assessed by non-invasive hish resolution B-mode ultrasonography in 66 T2DM patients and 33 controls.Plasma plasminogen activator inhibitor type-1(PAI-1)and fibrinogen(Fg)were measured.Results Frequencies of PAI-1 alleles and genotypes in T2DM patients and controls were all in accordance with the Hardy Weinberge quilibrium,without significant differences between T2DM patients and controls(P>0.05).PAI-1 and Fg were significantly higher in T2DM patients than in controls.There were significant differences in EDF and PAI- lamong different genotypes of PAI-1(P<0.05).Conclusion The PAI-1 genotype may affect EDF in T2DM pa- tients.
