Expression and significance of Survivin in esophageal carcinoma
- VernacularTitle:食管癌组织中Survivin蛋白的表达及其意义
- Author:
Zuoyu WU
;
Yuwen ZHOU
;
Qinggui CUI
;
Zhijuan ZHANG
- Publication Type:Journal Article
- Keywords:
Esophageal carcinoma;
Survivin;
Tumor-adjacent tissue
- From:
Clinical Medicine of China
2008;24(7):657-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of Survivin in esophageal car-cinoma.Methods Survivin expression was detected by immunohistochemistry in 61 cases of esophageal squamous carcinoma tissues and 26 tumor-adjacent normal tissues.Results The positive Survivin expression rate was 60.7% (37/61)in tumor tissues.The expression of Survivin was significantly correlated with the tumor grading,infiltration, lymph node metastasis and the survival(P<0.01).Conclusion Survivin may be an important marker for tumor di-agnosis and it is of great important to the active treatment of high-risk patients and to increasing of prognosis values.
