Delivering programmed death-1 inhibitory signal suppresses lupus-like syndrome in autoimmune BXSB mice
- VernacularTitle:重组腺病毒程序性死亡配体-1治疗BXSB狼疮鼠的实验研究
- Author:
Hanlu DING
;
Xiongfei WU
;
Yani HE
;
Jun WU
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
PD-1;
PD-L1;
BXSB mice
- From:
Chinese Journal of Rheumatology
2008;12(7):449-451
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of delivering programmed death (PD)-1 negative costimulation pathways in the prevention of murine BXSB lupus. Methods A recombinant adenovims containing the full-length mouse PD-L1 gene (AdPD-L1) was constructed and was introduced to the BXSB mice. The effect of immunoinhibitory receptor PD-1 on activated lymphocytes was investigated to evaluate its effect on prevention of lupus nephritis in BXSB mice. Results This intervention dramatically delayed the onset of proteinuria, effectively inhibited IgG autoantibody production, and significantly reduced hypercellularity and deposition of IgG in glomeruli, resulting in almost complete amelioration of lupus nephritis in these animals.Conclusion Our results suggest that simultaneous stimulation of PD-1-mediated pathway can potentially revent human lupus nephritis.
