Analysis of T lymphocyte subsets in patients with primary biliary cirrhosis
- VernacularTitle:原发性胆汁性肝硬化T淋巴细胞亚群分析
- Author:
Lixia GAO
;
Xuhua SHI
;
Zhifeng QIU
;
Fengchun ZHANG
;
Bin LIU
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis,biliary;
T-lymphocytes;
CD4+CD28-T cells;
CD8+CD28-T cells
- From:
Chinese Journal of Rheumatology
2008;12(7):477-479
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance and characteristics of T lymphocyte subsets and co-stimulatory CD28 in peripheral blood of patients with primary biliary cirrhosis. Methods Tri-colour flow-cytometry was used to detect the levels of T lymphocyte subsets in peripheral blood in 98 patients with primary biliary cirrhosis and 30 age and gender matched healthy controls. Results Compared to control group the percentage of CD4+ T increased and CD8+ T lymphocyte decreased in the PBC group. The CD4+/CD8+ ratio in the PBC group was higher than that in the control group (P<0.05). And the percentage of CD4+CD28- T cells and CD8+CD28- T cells increased, too (P<0.05). Conclusion There are immunological abnormalities in PBC and the expression of co-stimulator CD28 is significantly decreased. CD8+CD28-T lymphocytes may have immune regulatory effect in PBC.
