High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma.
10.3349/ymj.2015.56.5.1449
- Author:
Min Seok SEO
1
;
Ja Kyung KIM
;
Jae Yong SHIM
Author Information
1. Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. hope@yuhs.ac
- Publication Type:Case Reports
- Keywords:
High-dose vitamin C;
multiple pulmonary metastases;
hepatocellular carcinoma
- MeSH:
Aged;
Antineoplastic Agents/administration & dosage/*therapeutic use;
Ascorbic Acid/*administration & dosage/therapeutic use;
Carcinoma, Hepatocellular/*drug therapy/pathology;
Chemoembolization, Therapeutic;
Combined Modality Therapy;
Female;
Humans;
Liver Neoplasms/pathology/*therapy;
Lung Neoplasms/*drug therapy/pathology;
Neoplasm Recurrence, Local;
Niacinamide/analogs & derivatives/therapeutic use;
Phenylurea Compounds/therapeutic use;
Treatment Outcome
- From:Yonsei Medical Journal
2015;56(5):1449-1452
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of regression of multiple pulmonary metastases, which originated from hepatocellular carcinoma after treatment with intravenous administration of high-dose vitamin C. A 74-year-old woman presented to the clinic for her cancer-related symptoms such as general weakness and anorexia. After undergoing initial transarterial chemoembolization (TACE), local recurrence with multiple pulmonary metastases was found. She refused further conventional therapy, including sorafenib tosylate (Nexavar). She did receive high doses of vitamin C (70 g), which were administered into a peripheral vein twice a week for 10 months, and multiple pulmonary metastases were observed to have completely regressed. She then underwent subsequent TACE, resulting in remission of her primary hepatocellular carcinoma.
