Invasive Primary Colonic Aspergillosis in the Immunocompetent Host without Classical Risk Factors.
10.3349/ymj.2015.56.5.1453
- Author:
Seon Ah CHA
1
;
Mi Hee KIM
;
Tae Seok LIM
;
Hyun Ho KIM
;
Kyung Yoon CHANG
;
Hoon Suk PARK
;
Hyung Wook KIM
;
Seong Heon WIE
;
Dong Chan JIN
Author Information
1. Department of Internal Medicine, School of Medicine, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Korea. cttailor@catholic.ac.kr
- Publication Type:Case Reports
- Keywords:
Invasive aspergillosis;
colon perforation;
immunocompetent host
- MeSH:
Amphotericin B/administration & dosage/therapeutic use;
Antifungal Agents/administration & dosage/*therapeutic use;
Aspergillosis/*diagnosis/drug therapy/microbiology/surgery;
Aspergillus/*isolation & purification;
Colon/microbiology/radiography/*surgery;
Colonic Diseases/diagnosis/therapy;
Combined Modality Therapy;
Humans;
*Immunocompetence;
Laparotomy;
Male;
Middle Aged;
Treatment Outcome;
Voriconazole/administration & dosage/therapeutic use
- From:Yonsei Medical Journal
2015;56(5):1453-1456
- CountryRepublic of Korea
- Language:English
-
Abstract:
Invasive aspergillosis (IA), generally considered an opportunistic infection in immunocompromised hosts, is associated with high morbidity and mortality. IA commonly occurs in the respiratory tract with isolated reports of aspergillosis infection in the nasal sinuses, central nervous system, skin, liver, and urinary tract. Extra-pulmonary aspergillosis is usually observed in disseminated disease. To date, there are a few studies regarding primary and disseminated gastrointestinal (GI) aspergillosis in immunocompromised hosts. Only a few cases of primary GI aspergillosis in non-immunocompromised hosts have been reported; of these, almost all of them involved the upper GI tract. We describe a very rare case of IA involving the lower GI tract in the patient without classical risk factors that presented as multiple colon perforations and was successfully treated by surgery and antifungal treatment. We also review related literature and discuss the characteristics and risk factors of IA in the immunocompetent hosts without classical risk factors. This case that shows IA should be considered in critically ill patients, and that primary lower GI aspergillosis may also occur in the immunocompetent hosts without classical risk factors.
