Effects of the complexus of radix salviae miltiorrhizae and ligustrazin on the learning and memory ability in Alzheimer disease rats
- VernacularTitle:丹参川芎嗪混合液对痴呆样大鼠学习记忆障碍的影响
- Author:
Weiqian CAI
;
Jianchun MIAO
;
Youdi LUO
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Phytherapy;
Learning disorders;
Memory disorders;
Rats
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(7):1091-1092
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of the complexus of radix salviae miltiorrhizae and lignstrazin (DCs) on the learning and memory impairment in Alzheimer disease rats. Methods Rats were randomly divided in- to 5 groups(10 rats/group):normal eontrol group, Alzheimer disease model group toxified with AlCl3 and D-gal,3 groups toxified with AICl3 and D-gal,whieh were treated with the different drugs including piracetam and DCs1,2. After 80 days,step-through and morris water maze experiments were used to detect the learning and memory ability. Results Compared with Alzheimer disease model group,DCs obviously improved the learing and memory ability of Alzheimer disease rats,it is increased significantly that active reaction, and the number of active avoidance, improve achievement, evasion failed to reduce the number of passive evade significantly shorten the delay time in Des-treated group. Conclusion DCs markedly improved the learing and memory ability of Alzheimer disease rats.
