Mean color vessel density with contrast-enhanced ultrasound and microvessel density: comparative study
- VernacularTitle:原发性肝癌超声造影彩色血管密度与病理微血管密度的对比分析
- Author:
Yuzhen ZHAO
;
Junhua ZHOU
;
Chao DONG
;
Honglei LIU
;
Xiaodong ZHU
;
Xiaohua ZHAO
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Carcinoma,hepatocetlular;
Neovascularization,pathologic
- From:
Chinese Journal of Ultrasonography
2008;17(7):581-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between quantitative parameters with contrast-enhanced ultrasound-power Doppler(CEUS-PD) and mierovessel density (MVD) in hepatoeellular carcinoma (HCC). Methods Thirty-four cases with HCC underwent CEUS before operation. The satisfactory images were selected through CEUS-PD and analyzed with computer to calculate mean color vessel density(MCVD). The blood flows of focal lesions were graded into 0-Ⅲ based on the numbers of color vessels with CEUS-PD. The correlation between those parameters and MVD counted with immunohistochemistry was analyzed after operation. Results In 34 cases with HCC, the MCVD of focal lesions with CEUS-PD was 0. 17±0.09, the pathologic MVD was (62.59 ±23.96)/400 × after operation. The MCVD was positively correlated to MVD( r = 0. 56, P <0.05). In 34 cases HCC,3 cases were in grade Ⅰ , 12 cases were in grade Ⅱ , 19 cases were in grade Ⅲ. There was significant differences in pathologic MVD of every grade ( F = 8.06, P <0.05). But there was no linear tendency in the grades( F = 7.57, P<0. 05). Conclusions In focal lesions of 34 HCC, MCVD calculated with CEUS-PD was positively correlated to pathologic MVD. It can be used to evaluate tumor blood perfusion exactly before operation.
