Relationship between gastrin expression,and development of colorectal neoplasm and cell proliferation
- VernacularTitle:胃泌素表达与大肠肿瘤的发生和细胞增殖的关系
- Author:
Hong WANG
;
Kui ZHAO
;
Lin XU
;
Haijun MU
;
Yuankun ZHOU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasm;
Gastrin;
Ki67
- From:
Clinical Medicine of China
2008;24(7):640-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between gastrin expression and the development of coloreetal neoplasm and cell proliferation.Methods 15 samples of normal coloreetal mucosal tissue,21 samples of coloreetal adenomas and 70 samples of colorectal cancer were selected for evaluation of the expression of gastrin and Ki67 with immunohistochemieal method.Results In normal colorectal mucosal tissues.colorectal adenomas and coloreetal cancer,the positive rates of gastrin expression were 0.28.6%and 25.7%,respectively-which were signff-ieantly hisher in coloreetal cancer and adenomas groups than in the normal colorectal mucosal tissues(P<0.05).But there was no significance between colorectal cancer and adenomas(P>0.05).The positive expression rate of Ki67 with the obove samples were 40.0%,76.2%and 82.8%-respectively,with statistical results identical with results of gastrin(P<0.05).There was significant correlation between gastrin and Ki67[P<0.05).Conclusion Gastrin and Ki67 are highly expressed in eolorectal neoplasm.Gastrin miight play an important role in the carcinogen-esis and development of colorectal neoplasm,and might promote tumor cell proliferation.
