Detection of P-selection,nitric oxide,and high-sensitive-C-reactive protein in type 2 diabetes mellitus with macroangiopathy and their significance
- VernacularTitle:血清可溶性P-选择素、一氧化氮及超敏C-反应蛋白在2型糖尿病大血管病变中的关系
- Author:
Xueli ZHAO
;
Fang WANG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
P-selection;
Nitric oxide;
C-reactive protein;
Macroangiopa-thy
- From:
Clinical Medicine of China
2008;24(7):648-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between P-selection,nitric oxide(NO),high-sensitive-C-reactive protein(hs-CRP)and type 2 diabetes mellitus(T2DM)with macroangiopathy.Methods In sernm of 125 T2DM subjects(60 subjects with macroangiopathy and 65 subjects without macroangiopathy)and 55 normal controls,the activity of P-selection,NO and hs-CRP was detected by ELISA,Nitrate Reductase Assay and scattering immunoturbidimetric method,respectivley.Results The activity of serum P-selection and hs-CRP was significantly higher in diabetic macroangiopathie group than in non macroangiopathic group and control normal.Serum NO was significantly lower in diabetic rnacroanglopathic group than in non macroangiopathic group and control normal.Serum P-selection was positively correlated with hs-CRP-systolic blood pressure(SBP),LDL-C,and was negatively correla- ted with NO:P-selection,hs-CRP,LDL-C and SBP were independently risk factors for T2DM with macroangiopathy. Conclusion Determination of P-selection and NO is very important for prevention and diagnosis of diabetic mac- roangiopathy in early stage.
