The change of β cell function in postoperative critically ill patients
- VernacularTitle:术后重症患者β细胞功能改变初探
- Author:
Wei HE
;
Tongyan ZHANG
;
Yuan XU
- Publication Type:Journal Article
- Keywords:
Islet cell function;
Critically illness;
Insulin;
C peptide
- From:
Clinical Medicine of China
2008;24(7):678-679
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of β cell function in critically ill surgical patients and its re- lationship with prognosis.Methods 32 patients>16 years age with no history of diabetes who were admitted to sur- gical intensive care unit(SICU)were divided into two groups according to APACHE Ⅱ score.Blood sample Was taken on preoperative and postoprative 1st day for measures of fasting insulin(FINS)and fasting C peptide(FCP). The HOMA-β Was calculated.Results The level of FINS,FCP and HOMA-β were significantly decreased on first day after operation than preoperative in critical group.Compared with control group,The level of FINS.FCP and HO- MA-βwere significantly reduced on first day after operation-which had negative correlation with APACHE Ⅱ score, APACHE Ⅲ score and in charge days of ICU.Conclusion There is β cell dysfunction in critically ill Surgical pa- tients.β cell function in surgical critically ill patients is negatively correlated with APACHE Ⅱ SCOre-APACHE Ⅲ score and days of ICU.
