Experimental study on therapeutic effects of Ginsenoside on Alzheimer's disease
- VernacularTitle:人参皂甙对阿尔茨海默病治疗机制的实验研究
- Author:
Longan WANG
;
Yuhong MA
;
Wei LI
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Ginsenoside;
Inducible nitric oxide synthase;
Nitric oxide
- From:
Clinical Medicine of China
2008;24(7):680-682
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of ginsenoside on expression of inducible nitric oxide synthase and concentration of NO in THP-1 induced by amyloid beta(Aβ) in Alzheimer's disease. Methods The concentra- tion of nitric oxide was determined by Griess Reagent in supernatant of THP-1. The content of iNOS was measured by western blotting. Results The expression of iNOS of model group was significantly higher than those of control group. Compared with model group, the ginseng could reduce expression of iNOS and concentration of NO significant- ly in THP-1. Conclusion Ginsenoside can significantly inhibit the expression of iNOS, and reduce secretions of NO, so it may provide a novel therapy for AD.
