Relationship between simple obesity and fibrinogen Bβ-148C/T and Bβ448G/A gene polymorphism in children
- VernacularTitle:儿童单纯性肥胖与纤维蛋白原Bβ-148C/T、Bβ448G/A基因多态性关系的研究
- Author:
Jie GAO
;
Fengzhen ZHAO
;
Junling ZHANG
;
Hongfen LI
;
Xiaodong YUAN
- Publication Type:Journal Article
- Keywords:
Simple obesity;
Fibrinogen;
Gene;
Polymorphism;
Child
- From:
Clinical Medicine of China
2008;24(7):645-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between simple obesity and flbrinogen Bβ-148C/T and Bβ448G/A gene polymorphism in children and to provide theoretical basis for children's imple obesity prevention.Methods 5ml fasting blood sample was taken from each patient.PCR and restriction enzyme digestion were used to detect the fibrinogen Bβ-148C/T and Bβ448G/A gene genotype.Results The genotype distribution of Bβ-148C/T was significantly different between simple obesity and normal controls(CC51/67, CT47/37 ,TT8/2, P =0.03 );The allele frequency in the children with simple obesity was higher than that of the healthy controls{ C 149/171 ,T63/41 ,P = 0.02).However, there was no significance between two groups in genotype distribution of Bβ 448G/A and allele frequency (GG61/69, AG41/32, AA4/5, G163/70, A49/42, P > 0.05 ). Conclusion There is significant cor-relation between simple obesity and fibrinogen Bβ-148 gene polymorphism in children but not between simple obesityand fibrinogen Bβ 448G/A gene polymorphism.
