Assessment of the effects of mesenchymal stem cell transplantation in the treatment of myocardial infarction at high altitude area
- VernacularTitle:门控心肌灌注显像评价高海拔地区骨髓干细胞移植治疗心肌梗死的疗效
- Author:
Hairu SHE
;
Pinfa LIU
;
Qin GAO
;
Youfu TONG
;
Hong XUE
- Publication Type:Journal Article
- Keywords:
Coronary arteriosclerotic heart disease;
Autologous mesenchymal stem cell transplantation;
Gated myocardial perfusion imaging
- From:
Clinical Medicine of China
2008;24(7):653-654
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of cardiac function and myocardial perfusion by Gated 99Tcm-MIBI myocardial perfusion imaging after autologous mesenchymal stem cell implantation in patients with acute myocardial infarction at high altitude area.Methods 33 patients with anteroseptal myocardial infarction were ran- domly divided into two groups.18 patients (control group) underwent percutaneous tranluminal coronary angioplasty (PTCA) and 14 cases (transplantation group) received additional mesenchymal stem cell transplantation.Myocardi- al perfusion imaging were performed in all patients before and at 6 and 12 months after treatment.Results Com- pared to pre-implantation,LVEF of transplantation group was improved 8%～9%after 6 months.The improving lev- els of control group were lower.However,there were not statistical differences among all data.Conclusion Mesen- chymal stem cell transplantation could improve myocardial systolic function and myocardial perfusion.
