Study of the expression of osteopontin in epithelial ovarian cancer tissue and serum
- VernacularTitle:骨桥蛋白在卵巢上皮癌组织和血清中的表达及其意义
- Author:
Xiaoyu DONG
;
Jinghua YANG
;
Huilan WANG
;
Li FENG
;
Cuixin HAN
- Publication Type:Journal Article
- Keywords:
Epithelial ovarian cancer;
Ostsopontin;
Benign ovarian tumor
- From:
Clinical Medicine of China
2008;24(8):760-762
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and signficance of the osteopontin (OPN) in epithelial ovarian cancer tissue and serum. Methods Immunohistochemistry method and ELISA were used to detect the expression of OPN in 64 cases of epithelial ovarian cancer tissue and serum, 20 cases of ovarian benign tumors and 10 cases of ovarian nomal tissues. Results The OPN expression was associated with the clinical staging and histological grading of epithelial ovarian cancer tissue and serum (P < 0.01). The level of OPN in epithelial ovarian cancer tissue was significantly higher than that in benign ovarian tumor and normal control groups (P < 0.01). Conclusion OPN is remarkably correlated with the carcinogenesis and the development of epithelial ovarian cancer.
