Progression of research of MDR1 single nucleotide polymorphism
- VernacularTitle:多药耐药基因1多态性研究进展
- Author:
Qin DU
- Publication Type:Journal Article
- Keywords:
Drug resistance,multiple;
Genes,MDR;
P-glycoprotein
- From:
Journal of International Oncology
2008;35(7):494-496
- CountryChina
- Language:Chinese
-
Abstract:
P-glycoprotein(P-gp),the product of multidrug resistance gene MDR1,plays a very significant role in the ADME processes(absorption,distribution,metabolism,excretion)and drug-drug interaction of drugs in human.The magnitude of resistance depends on the expression of MDR1 up-regulated by chemotherapy.DNA sequence differences ale associated with phenotypic variation by various mechanisms,single-nucleotide polymorphisms(SNPs)is the most common of them.Genetic polymorphisms of MDR1 are associated with alteration in P-gp expression and function in different ethnicities and subjects.
