Association of the polymorphism of A9570G in ACE2 gene with the genetic predisposition of diabetic nephropathy
- VernacularTitle:糖尿病肾病遗传易感性与血管紧张素转化酶2基因A9570G多态性的关系
- Author:
Wenzhong CHEN
;
Zhiliang LI
;
Ming LI
;
Chunsheng XU
;
Peng WU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Angiotensin 1 converting enzyme 2;
C,ene;
Polymorphisms;
A9570G;
Genetic predisposition
- From:
Clinical Medicine of China
2008;24(8):739-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of the polymorphism of A9570G in ACE2 gene with the genetic predisposition of diabetic nephropathy (DN). Methods 312 patients with type2 diabetes(T2DM) were included in the study. All the patients were divided into DM group and DN group according to if onset of DN. PCRRFLP were used to observe the association of polymorphisms of A9570G in ACE2 gene with DN. Results G allele frequencies of male subjects were 57.9% in DM patients and 67.5% in DN patients (X2 = 1. 559 ,P =0.212) ,52. 4% and,52.1% in female DM and DN patients (X2 =0. 003 ,P =0.955). In female patients,genetype in DN patiants had no difference from that in DM patients (X2 = 0. 109, P = 0. 947). Conclusion The polymorphism of A9570G in ACE2 gane may not associated with the genetic predisposition of DN.
