Angiotensin-(1-7) inhibit the expression of c-fos in angiotensin II-induced proliferative glomerular mesangial cells
- VernacularTitle:血管紧张素-(1-7)抑制肾小球系膜细胞增殖过程中c-fos蛋白表达
- Author:
Hongyan HE
;
Ning SHEN
;
Jian LIU
;
Xiaoling SHI
;
Mingyong WANG
- Publication Type:Journal Article
- Keywords:
Angiotensins;
Kidney glomerulus;
Cell proliferation;
Proto-oncogene protein c-fos
- From:
Journal of Chinese Physician
2008;10(7):868-870
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of angiotensin-(1-7) on the expression of cellular c-fos in angiotensin II -induced proliferative glomerular mesangial cells (GMC). Methods GMC were treated with angiotensin II and different dose of angiotensin-(1-7). GMC number were evaluated by crystal violet staining and the expression of c-foe were detected by western blot. Results Angiotensin-(1-7) inhibit angiotensin II -induced GMC proliferation as well as the expression c-foe in a concentration dependent manner. Conclusion c-fos is involved in the inhibiting effects of angiotensin-(1-7) on angiotensin II -induced GMC proliferation.
