Study on relationship between serum total IgE and β《,2》-adrenoreceptor polymorphism in asthmatic patients
- VernacularTitle:支气管哮喘IgE水平与β2-肾上腺素能受体基因多态性关系的研究
- Author:
Xianwei YE
;
Duanxing FENG
;
Xiangyan ZHANG
;
Hong YU
;
Xiaoyuan DIAO
- Publication Type:Journal Article
- Keywords:
Asthma;
Immunoglobulin E;
Receptors,adrenergic,beta-2;
Polymorphism,genetic
- From:
Journal of Chinese Physician
2008;10(7):920-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association between serum total IgE level and β2-adrenoreceptor polymorphism (β2-AR) in asthmatic patients. Methods ELISA was used to determine serum total IgE and AS-PCR was used to determine β2-adrenoreceptor polymor- phism in 44 asthmatic patients. Results In β2-AR 16 locus genotype, the distribution frequencies of Arg/Arg, Gly/Gly showed increasing tendency, whereas Arg/Gly showed decreasing tendency, in normal serum total IgE group and increased serum total IgE group. But there was no significant difference between this two groups. In β2- AR 27 locus genotype, the distribution frequency of Gln/Gln genotype accounts for 76.2% and Gln/Glu genotype for 19.0% in increased serum total IgE group, while Gln/Gln genotype accounts for 9.0% and Gln/Glu geno- type for 73.9% in normal serum total IgE group. There was significant difference between two groups ( P<0.01 ). Conclusions Serum total IgE was correlated with β2-AR 27 locus genetic polymorphism, which may contribute to understand the mechanism of asthma in the peo- ple of the Han nationality in GuiZhou.
