Clinical and Empirical Study on Cerebral Infarction of Phlegm-heat Accumulated in Large Intestime and Wind-phlegm Invading Upward Type Treated by Tongfu Xingshen Oral Liquid
- VernacularTitle:通腑醒神口服液治疗痰热腑实、风痰上扰型脑梗死的临床及实验研究
- Author:
Xuequan LONG
- Publication Type:Journal Article
- Keywords:
Tongfu Xingshen Oral Liquid;
Cerebral infarction of phlegm-heat accumulated in large intestine and wind-phlegm invading upward type
- From:
International Journal of Traditional Chinese Medicine
2008;30(4):247-249
- CountryChina
- Language:Chinese
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Abstract:
Objective To study the therapeutic effect of Tongfu Xingshen Oral Liquid on the cerebral infarction of phlegm-heat accumulated in large intestime and wind-phlegm invading upward type and the impact of this Oral liquid on plasma ET-1,TNF-α and the blood viscosity.Methods 60 cases of cerebral infarction patients were randomly divided into Tongfu Xingshen Oral Liquid treatment group(n=30)and conventional therapeutic group(n=30).Besides Routine treatment was used in the two groups,the Tongfu Xingshen Oral Liquid,100ml twice dally,was added in the treatment group.The course of treatment for both groups was 20 days.RIA,double-antibody sandwich enzyme-linked immunosorbent assay (ELISA)and LG-R-80A hemorbeology instrument were used to determine the level of all patients'plasma ET-1,serum TNF-α,blood viscosity,before and after the treatment.Meanwhile,neurological impairment scale Was assayed before and 28 days after the treatment.30 healthy people were recruited as controls.Results The plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value.RBC hardness plot,fibrinogen(FI)levels in cerebral infarction patients were significantly higher than healthy people.The plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value,RBC hardness plot,fibrinogen(FI)level were positively correlated with the acute cerebral infarction.Thetotal efficiency of the treatment group(90%)was significantly higher than that of the conventional group(72.5%,P＜0.05).The plasma ET-1,serum TNF-α,whole blood viscosity value,Plasma viscosity value,RBC hardness plot,fibrinogen(FD levels were decreased after treatment in the both groups,while the reductions in the treatment group were more obvious than in the conventional therapy group(P＜0.05).Conclusion Tongru Xinshen Oral Liquid can improve the prognosis of cerebral infarction by degrading plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value,RBC hardness plot,fibrinogen(FI)of acute cerebral infarction patients and degrading cerebrovascular endothelial cells damage,improvingthe clinical symptoms and rehabilitating of neurological defects,.
