Brain protection of adenosine preconditioning in infants undergoing radical correction for fallot tetrad
- VernacularTitle:腺苷预处理对行法洛四联症根治术婴幼儿的脑保护作用
- Author:
Lihua CHEN
;
Qian LI
;
Linli LIU
- Publication Type:Journal Article
- Keywords:
Open heart surgery;
Adenosine;
infant;
S-100β;
Neurone specific enolase
- From:
Clinical Medicine of China
2008;24(8):749-750
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the brain protection of adenosine preconditioning in infants with tetralngy of Fallot (TOF) undergoing open heart surgery. Methods 120 patients with TOF undergoing open heart surgery were randomly divided into two groups: adenosine group and control group. Total dosage of 1.5 mg/kg adenosine was intravenously dripped in the adenosine group before the cardiopulmonary bypass. Serum S-100β and neurone specific enolase (NSE) were measured before the cardipulminary bypass, 30 min and 12 hours after the aorta off clamping. Results At 30 min and 12 hour after opening the aorta, the S-100β[(0. 346±0. 162)μg/L vs. (0.717±0.260) μg/L and (0.541±0.272) μg/L vs. (1.140±0.567) μg/L,P <0.001 ]and NSE[(10.43±5.54) μg/L vs. (15.75±7.96)μg/Land (15.54±7. 98)μg/L vs. (23.67±8.00)μg/L,P<0.001]were both lower in adenosine group than that in control group. Conclusion Adenosine preconditioning can reduce the S-100β and NES in infants with TOF undergoing open heart surgery and has brain protection.
