Expression and significance of Paxillin and VCAM-1 proteins in esophageal carcinoma
- VernacularTitle:食管鳞癌组织中桩蛋白和血管细胞粘附分子-1的表达及其意义
- Author:
Lei WANG
;
Ming HE
;
Tao LIU
;
Xianli MENG
;
Shixiang BAI
;
Yumin PING
- Publication Type:Journal Article
- Keywords:
Esophageal squamoas cell carcinoma;
Paxillin;
VCAM-1;
Immunohistochemistry
- From:
Clinical Medicine of China
2008;24(8):757-759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Paxillin and VCAM-1 in esophageal carcinoma and the relationship between the expression of Paxillin, VCAM-1 and carcinogenesis and progression of esophageal carcinoma. Methods Paxillln and VCAM-1 expression were detected in 24 normal esophageal mucosa and 94 primary tumor tissues with SP immunohistochemistal method. Results The expression rate of PaxiUin was related to invasive depth (P <0.01) ,clinical staging (P <0.01) and metastasis of lymph node (P <0.05). The expression rate of VCAM-1 was related to invasive depth (P < 0.01) ,clinical staging (P < 0.01) and metastasis of lymph node (P<0.05). There was a positive correlation between Paxillin and VCAM-1 expression in this study (r = 0. 247 ,P < 0.05). Conlusion Paxillin and VCAM-1 are over expressed in esophageal carcinoma. They can be used as valuable biomakers to evaluate biological characteristics in esophageal carcinoma.
