Relationship of serum C reactive protein level with serum leptin concentration in type 2 diabetic patients
- VernacularTitle:2型糖尿病患者血清超敏C-反应蛋白与血清瘦素的相关性
- Author:
Yanju HE
;
Huimin BI
;
Zhenhua LIU
;
Dong LI
;
Pingan ZHANG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Leptin;
High-sensitivity creactive protein
- From:
Clinical Medicine of China
2008;24(8):806-808
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of serum high-sensitivity C reactive protein (hs-CRP) level with leptin in patients with type 2 diabetes mellitns (T2DM). Methods 35 cases of T2DM patients were involved in the study and 16 normal subjects were taken as controls. Fasting serum leptin and CRP were measured .The relationship between them were also analyzed. Results Fasting serum hs-CRP concentration in T2DM group was higher than that in healthy control group, but serum ieptin levels is the same (P > 0.05). Partial correlation analysis demonstrated that fasting hs-CRP level was positively correlated with leptin (r =0.512 ,P =0. 018). Conclusion Fasting serum hs-CRP level is significantly raised in T2DM ,which is associated with leptin. There is chronic inflammatory reaction in T2DM patients,and leptin is possibly involved in inflammatory pathogenesis of T2DM.
