Study on Protective Function of Total Saponin of Radix Dipsaci of Sichuan on Focal Cerebral Ischemia Injury in Rats
- VernacularTitle:川断总皂苷对大鼠局灶性脑缺血损伤保护作用的实验研究
- Author:
Jiantao LV
;
Ning ZOU
- Publication Type:Journal Article
- Keywords:
Total saponin of Radix Dipsaci of Sichuan;
Cerebral ischemia
- From:
International Journal of Traditional Chinese Medicine
2008;30(4):245-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective funcfon of total saponin of Radix Dipsaci of Sichuan on cerebral ischemia.Methods 40 rats were randomly divided into a nonllal group,a model group,a low-dose total saponin(10 blocking middle cerebral artery with interpolation method.Brain homogenate was extracted,and superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)in the brain homogenate were measured.Results In the low-dose and high-dose total saponin groups.the infarction area of cerebral ischcmia and the content of MDA were significantly reduced and the activity of SOD and GSH-Px were increased.Conclusion Total saponin of Radix Dipsaci of Sichuan has obvious protective function on focal cerebral ischemia.
