Relationship between TNF-α polymorphisms in its promotor region and susceptibility of lung cancer
- VernacularTitle:TNF-α启动子区域基因多态性与肺癌易感性
- Author:
Xinshuang YU
;
Jing LIANG
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-alpha;
Polymorphism,genetic;
Lung neoplasms
- From:
Journal of International Oncology
2008;35(7):505-507
- CountryChina
- Language:Chinese
-
Abstract:
Genetic susceptibility of lung cancer plays an important role in genesis of lung cancer.Studies find that tumor necrosis factor α(TNF-α)is significantly up-regulated in lung cancer patients.It may be correlated with the TNF-α polymorphism in its promoter region which affects its transcription and expression.TNF-α polymorphisms may be an important genetic marker for susceptibility of lung cancer.
