Correlation between formation of portal vein tumor thrombus and liver cancer stem cells metastasis
- VernacularTitle:门静脉癌栓形成与肝癌干细胞转移的关系
- Author:
Huasheng HU
;
Jie SHI
- Publication Type:Journal Article
- Keywords:
Portal vein;
Neoplasm circulating cells;
Tumor stem cells;
Neoplasm metastasis
- From:
Journal of International Oncology
2008;35(7):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies about stem cells show that the formation of portal vein tumor thrombus(PVTT)is closely relative to the metastasis of liver cancer stem cells induced by portal vein microenvironment.Liver cancer stem cells first detach from the primary tumor,extravasate to extracellular matrix,stimulate angiogenesis or intravasate and migrate through the systemic circulation,evade host defense mechanisms,migrate to specific blood vessel sites through chemo-taxis and attach to blood vessel wall,then extravasate through blood vessel and home to specific microenvironment and to form PVTT.
