Targeted therapy of soft tissue sarcoma
- VernacularTitle:软组织肉瘤靶向治疗进展
- Author:
Jun GUO
- Publication Type:Journal Article
- Keywords:
Soft tissue neoplasms;
Antineoplastic agents;
Drug therapy
- From:
Journal of International Oncology
2008;35(7):541-543
- CountryChina
- Language:Chinese
-
Abstract:
The results of chemotherapy in the treatment of soft tissue sarcoma seem to have reached a plateau.Targeted therapy is the key to improve curative efficacy.Although there are many kinds of targeted therapy drugs of the first generation,only several targeted drugs that target angiogenesis and the epidermal growth factor receptor have showed survival benefits in prospective,randomized,phase Ⅲ clinical trials.Recent data suggest that multitargeted inhibitors might have greater activity owing to their ability to simultaneously block several key signaling pathways.Preliminary results of such agents in clinical trials show that they have a well tolerated toxicity profile,and might have a promising vahle in the treatment of soft tissue sarcoma.
