The measurement and clinic significance of tissue Inhibitors of metalloproteinase-1 on children with myocardltis
- VernacularTitle:儿童心肌炎基质金属蛋白酶组织抑制因子-1检测与临床意义
- Author:
Zhan WANG
;
Xiaozhong HUANG
;
Wei PAN
;
Hui DONG
;
Zhengxiang ZHANG
;
Yiquan WU
;
Shuguang LIN
;
Yuan CAO
;
Zhifeng ZHANG
- Publication Type:Journal Article
- Keywords:
Tissue inhibitors of metalloproteinase-1;
Myocarditis;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(7):1141-1143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between serum tissue inhibitors of metaUoproteinase-1 and children with myocarditis,and provide evidences to support the measurement of serum tissue inhibitors of metallopro- teinase-1. Methods Tissue inhibitors of metalloproteinaee-1 and bioehem indexes of the harvested specimens and e -chocardiogram were measured from children with myocarditis(age: 1～14 years old, n = 9) and healthy young chil- dren(age: 1～14 years old, n = 9). Results Children with myocarditis showed reduced ejection fraction and dilated left ventricular compared with healthy children. Tissue inhibitors of metalloproteinaee-1 in children with myocarditis was significantly reduced compared with healthy children. Aspartie acid transanainase, lactate dehydrogenase,creatine kinase, hydroxybutyrie acid dehydrogenase, MB isoenzyrne of creatine kinase, cardiac troponin Ⅰ , C reactive protein showed no difference between two groups. Conclusion The reduced serum level of tissue inhibitors of metallopro- teinase-1 may show the severity of children with myocarditis and maybe one of the mechanisms of children with di- lated cardiomyopathy following myocarditis.
