The changes and clinical significance of thyroid hormone levels in old patients with sepsis
- VernacularTitle:老年脓毒症患者甲状腺激素水平变化与临床意义
- Author:
Changyuan WANG
;
Jian QIN
;
Jing WANG
;
Changyi SUN
- Publication Type:Journal Article
- Keywords:
Sepsis;
Thyroid hormones;
Multiorgan dysfunction syndrome
- From:
Clinical Medicine of China
2008;24(8):790-791
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of thyroid hormone levels and its relationship with prognosis in old patients with sepsis. Methods APACHE Ⅱ score and SIRS score were documented in 140 old patients with sepsis,who were divided into Multiorgan dysfunction syndrome (MODS) group and non MODS group. Results The levels of FT3 and FT4 descended obviously and APACHE Ⅱ score and SIRS score increased remarkably in old patients with severe sepsis(P <0.05 or P <0.01). The level of FT3 and FT4 in death group and MODS group was much lower than that in the survival group (P < 0.05). Conclusion Inflammatory resction and eytokines may effect the hypothalamic- pituitary-thyroid axis. The levels of thyroid hormone can reflect old patients with sepsis condition. The patients with severer conditions may have lower levels of thyroid hormone who will be more likely to died of MODS.
