Expression of CDIIa, CDIIb and CD62L genes in Mesangial Proliferative Glomerulonephritis
- VernacularTitle:原发系膜增殖性肾小球肾炎患者中性粒细胞和内皮细胞活化状态研究
- Author:
Xi ZHANG
;
Liqiong WANG
;
Huirong ZHU
;
Dagang LIU
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis,membranoproliferative;
Antigens,CD11a;
Antigens,CD11b;
L-selectin;
Neutrophils;
Endothelialcells
- From:
Journal of Chinese Physician
2008;10(7):876-878
- CountryChina
- Language:Chinese
-
Abstract:
Objective The person's Mesangial Proliferative Glomemlonephritis (MsPGN) were divided into 3 types based on clini- cal manifestations: nephroticsyndrome, hematuria and proteinuria. To investigate the expression of CD11a, CD11b, CD62L and its signifi- cance in the kidneys patients with MsPGN. Methods CD11a, CD11b and CD62L expression in blood of MsPGN patients (n=35) were investigated by flow eytometry method, and the changes of these proteins in kidney were surveyed. Results In MsPGN, CD11a and CD11b expression in blood were significandy lower and CD62L expression in blood were markedly higher than that in normal humans. And the renal glomeruli of MsPGN also expressed CD11a, CD11b and CD62L. Conclusion The expression of CD11a, CD11b and CD62L are abnormal in MsPGN, and apoptosis may play certain role in the pathogenesis of MsPGN.
