Application of low-dose glucocorticoids In septic shock
- VernacularTitle:小剂量糖皮质激素在感染性休克患者中的应用
- Author:
Hong CHEN
;
Jianguo JIA
;
Fei LI
;
Lei YANG
;
Dachnan HU
;
Peng YANG
;
Jiabang SUN
- Publication Type:Journal Article
- Keywords:
Septic shock;
Glucocorticoids;
Hemodynamics;
Multiorgan dysfunction syndrome
- From:
Clinical Medicine of China
2008;24(8):802-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of low-dose glucocorticoids in improving prognosis and adjusting septic shock. Methods A total of 46 patients with a confirmed diagnosis of septic shock were retrospaetivley analyzed. 24 patients without glucocorticoids treatment were taken as control group; 22 patients with glucocorticoids as therapy group (n = 22). The two group received standard treatment for septic shock. Results The percentage of shock reversal on day 7 was higher in therapy group than that in control group (P <0.05). However,there were notstatistical significances in the duration of mechanical ventilation, the length of ICU stay, the incidence of multiple or-gan dysfunction syndrome (MODS) and mortality between the two groups (P > 0.05). Conclusion Low-dose glucocorticoids can effectively accelerate refractory septic shock reversal and vasopreasor withdrawal. This seems to be related to the reduced production of CRP but the beneficial effects of low-dose steroids regimens on long-term outcome have not yet be determined.
