Influence of nebulized Pulmicort respules inhalation after endoscopic sinus surgery on expression of ENaC protein
- VernacularTitle:鼻内窥镜术后普米克令舒鼻雾化吸入对ENaC蛋白表达的影响
- Author:
Yiming JIANG
;
Xucheng JIANG
;
Jiping LI
;
Chun ZHANG
;
Jiadong WANG
- Publication Type:Journal Article
- Keywords:
nasal polyp;
residual middle turbinate;
epithelial sodium channel;
Pulmieort respules;
nebulized inhalation
- From:
Journal of Shanghai Jiaotong University(medical Science)
2010;30(1):80-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of nebulized Pulmieort respules inhalation after endoscopic sinus surgery (ESS)on the expression of epithelial Na~+ channel(ENaC)protein in nasal mucosa. Methods Forty-four patients with nasal polyps undergoing ESS were randomly divided into Pulmieort respules treatment group(n=21,nebulized Pulmieort respules inhalation for 10 d after ESS)and Rhinocort control group(n=23,Rhinoeort aqueous nasal spray for 10 d after ESS).All the patients were performed biopsy of membrane on the residual middle turbinate 14 d after ESS,eosinophils (Eos)and neutrophils(Neu)per hundred inflammation cells were counted under microscope during ESS and after ESS,and the expression of ENaC protein was detected by immunofluorescence assay. Results The percentages of Eos and Neu decreased in two groups after treatment,and the percentage of Neu in Pulmieort respules treatment group was significantly lower than that in Rhinoeort control group(P<0.05).The expression of ENaC protein after treatment in Pulmieort respules treatment group was significantly lower than that in Rhinoeort control group(P<0.01). Conclusion Application of pulmieort respules after ESS can decrease Neu infiltration and inhibit expression of ENaC protein,which can relieve acute inflammation and edema of nasal mucosa.
