Diagnosis and treatment of pediatric and hebetic adrenocorticotropic hormone secreting pituitary microadenoma
- VernacularTitle:儿童和青春期垂体促肾上腺皮质激素微腺瘤的诊断和治疗
- Author:
Jianxiang ZHAO
;
Hua HE
;
Kaijun ZHAO
;
Liuguan BIAN
;
Qingfang SUN
;
Jiankang SHEN
- Publication Type:Journal Article
- Keywords:
pituitary adenoma;
adrenocorticotropic hormone;
microadenoma;
Cushing's disease;
bilateral inferior petrosal sinus sampling;
paediatric;
hebetic
- From:
Journal of Shanghai Jiaotong University(medical Science)
2010;30(1):88-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the methods of diagnosis and treatment of pediatric and hebetic adrenocorticotropic hormone ( ACTH) secreting pituitary microadenoma. Methods The data of 10 patients with ACTH secreting pituitary microadenoma were retrospectively analysed. ACTH secreting pituitary microadenoma was diagnosed by clinical manifestations, biochemical and imaging findings, and 5 patients underwent bilateral inferior petrosal sinus sampling ( BIPSS). Transsphenoidal surgery was performed on all the patients under microscope, and the tumor specimens were detected by immunohistochemistry. Results Immunohistochemical examination revealed that ACTH was positive in 8 cases and negative in 2 cases. Patients were followed up for 12 to 63 months, 7 cases (70%) were cured, one (10%) achieved remission, and the other two (20%) experienced recurrence. Conclusion BIPSS is helpful in the diagnosis and localization of pediatric and hebetic ACTH pituitary microadenoma, and transsphenoidal surgery is the optimal choice of treatment.
