Research progress of role of innate immunity in infection of leptospira
- VernacularTitle:固有免疫在钩端螺旋体感染中作用的研究进展
- Author:
Cong DENG
;
Xiaokui GUO
;
Xucheng JIANG
- Publication Type:Journal Article
- Keywords:
leptospirosis;
innate immunity;
macrophage
- From:
Journal of Shanghai Jiaotong University(medical Science)
2010;30(1):94-97
- CountryChina
- Language:Chinese
-
Abstract:
Leptospirosis is an important zoonosis with worldwide distribution. As the first procedure in immunity system, the role and significance of innate immunity in controlling infection at the early stage of the disease have gradually been emphasized. Macrophages can phagocytize and kill leptospira, while the pathogenic leptospira can evade the killing by macrophages. In addition, neutrophils, complement system and cytokines also contribute to the defence of leptospira infection.
