Asymmetric Dimethylarginine and Stroke
- VernacularTitle:非对称性二甲基精氨酸与卒中
- Author:
Huijuan WEN
;
Jiandong JIANG
- Publication Type:Journal Article
- Keywords:
asymmetric dimethylarginine;
stroke;
nitric oxide;
endothelial dysfunction
- From:
International Journal of Cerebrovascular Diseases
2008;16(7):550-554
- CountryChina
- Language:Chinese
-
Abstract:
Asymmetric dimethylarginine(ADMA)is a nitric oxide synthase(NOS)inhibitor.ADMA is formed by methylation of L-arginine residues.It innbits the formation of vasoactive substances(nitric oxide),resulting in endothelial dysfunction and vaseular diseases.A number of studies have suggested that ADMA may be a risk factor for stroke.The expression of ADMA increases significantly in patients with hyperhomocysteinemia,carotid stenosis and cardiovascular disease.
