Advancement on targeted therapy of malignancies with superantigens
- VernacularTitle:超抗原靶向抗肿瘤研究进展
- Author:
Lin HAO
;
Zhen GONG
- Publication Type:Journal Article
- Keywords:
Superantigen;
Neoplasms;
Targeted therapy
- From:
Journal of International Oncology
2008;35(7):486-488
- CountryChina
- Language:Chinese
-
Abstract:
Superantigens are potent activators of T cells,causing rapid and massive proliferation of T cells and superantigen-dependent-cell-mediated cytotoxicity with extremely low doses.However such antitumor effects lack selectivity.Thus with the methods including monoclonal antibody targeting or binding superantigens to the surface of tumor cells as well as genetic engineering,scientists have done lots of work on targeted therapy of malignancies with superantigen.
