Effects of benazepril on yon Willebrand factor and albuminuria in patients with type 2 diabetes mellitus associated with hypertension
- VernacularTitle:盐酸贝那普利对2型糖尿病并高血压患者血管性血友病因子及尿白蛋白的影响
- Author:
Shuying LI
;
Gang WEI
;
Yuehua LI
;
Qiudi JI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Angiotensin-converting enzyme inhibitors
- From:
Chinese Journal of General Practitioners
2008;7(8):564-566
- CountryChina
- Language:Chinese
-
Abstract:
Fifty-six hypertensive diabetic patients (glyeosylated hemoglobin A1c<7%)with albuminuria were randomly assigned to benazepril (10 mg/d,n=28) or amlodipine (5 mg/d,n=28) group.Blood pressure was measured at the end of 4-week treatment.Benazepril and amlodipine were increased to 20 mg/d and 10 mg/d respectively when blood pressure>130/80 mm Hg.All the patients were treated for 12 weeks.In both groups,plasma yon Willebrand factor and urine albumin decreased significantly from baseline.Except for urine albumin,no significant inter-group difference in plasma van Willebrand factor and target blood pressure was observed.Benazepril and amledipine seem to show similar efficacy in lowering blood pressure and improving endothelial function,but benazepril may be more effective in kidney protection.
