The Severity of Acute Lung Injury in Experimental Acute Pancreatitis.
- Author:
Kwang Hee KIM
1
;
Chang Duck KIM
;
Young Sik KIM
;
Jin Hai HYUN
Author Information
1. Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Acute pancreatitis;
Severity;
Lung injury;
Rat
- MeSH:
Acute Lung Injury*;
Adult;
Amylases;
Animals;
Bronchoalveolar Lavage;
Ceruletide;
Humans;
Infusions, Intravenous;
Lung;
Lung Injury;
Male;
Neutrophils;
Pancreas;
Pancreatitis*;
Pleural Effusion;
Pulmonary Edema;
Rats;
Rats, Sprague-Dawley;
Taurocholic Acid
- From:Korean Journal of Medicine
1998;55(3):295-301
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: About 60% of all deaths due to acute pancreatitis occur within the first 7 days of onset and associated with acute lung injuries. Lung injury include pulmonary infiltration, pulmonary edema, pleural effusion, and adult respiratory ditress syndrome. But it is unclear whether the acute lung injury is related with severity of pancreatitis. In this study, we have evaluated the association between acute lung injury and severity of pancreatitis in experimental acute pacreatitis. METHODS: Twenty-one male Sprague-Dawley rat (200-250 g B.wt) were used. There were three groups: control (group 1, n=7), edematous pancreatitis (group 2, n=7), and necrotizing pancreatitis (group 3, n=7). For inducing a edematous pancreatitis, rat was received a 4 hour intravenous infusion of cerulein (5micro/kg/hr). For a necrotizing pancreatitis, rat was received intraductal injection of taurocholate (5%, 0.1ml/100 g B.wt). After pancreatitis was induced, the pancreas, lung and blood were prepared for biochemical and histologic changes each other. Bronchoalveolar lavage (BAL) was also taken. RESULTS: Cerulein induced edematous pancreatitis and taurocholate induced necrotizing pancreatitis. Amylase was significantly increased in edematous and necrotizing pancreatitis. BAL findings showed that neutrophil was increased from 2% to 49% in necrotizing pancreatitis. The severity of lung injury was more severe in necrotizing pancreatitis than edematous pancreatitis. CONCLUSION: These observations suggest that the lung injury was strongly associated with severity of acute pancreatitis and neutrophil may be capable of important role in the development of lung injury.
